Efficacy of Histone Deacetylase and Estrogen Receptor Inhibition in Breast Cancer Cells Due to Concerted down Regulation of Akt
- Author(s): Munster, Pamela
- Thomas, S
- Thurn, KT
- Raha, P
- Chen, S
- Munster, PN
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3711340?pdf=render
Hormonal therapy resistance remains a considerable barrier in the treatment of breast cancer. Activation of the Akt-PI3K-mTOR pathway plays an important role in hormonal therapy resistance. Our recent preclinical and clinical studies showed that the additi
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