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Open Access Publications from the University of California

Efficacy of Histone Deacetylase and Estrogen Receptor Inhibition in Breast Cancer Cells Due to Concerted down Regulation of Akt

  • Author(s): Munster, Pamela
  • Thomas, S
  • Thurn, KT
  • Raha, P
  • Chen, S
  • Munster, PN
  • et al.

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Hormonal therapy resistance remains a considerable barrier in the treatment of breast cancer. Activation of the Akt-PI3K-mTOR pathway plays an important role in hormonal therapy resistance. Our recent preclinical and clinical studies showed that the additi

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