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Shrink-film configurable multiscale wrinkles for functional alignment of human embryonic stem cells and their cardiac derivatives

  • Author(s): Chen, A
  • Lieu, DK
  • Freschauf, L
  • Lew, V
  • Sharma, H
  • Wang, J
  • Nguyen, D
  • Karakikes, I
  • Hajjar, RJ
  • Gopinathan, A
  • Botvinick, E
  • Fowlkes, CC
  • Li, RA
  • Khine, M
  • et al.
Abstract

A biomimetic substrate for cell-culture is fabricated by plasma treatment of a prestressed thermoplastic shrink film to create tunable multiscaled alignment "wrinkles". Using this substrate, the functional alignment of human embryonic stem cell derived cardiomyocytes is demonstrated. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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