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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
- Sims, Rebecca;
- van der Lee, Sven J;
- Naj, Adam C;
- Bellenguez, Céline;
- Badarinarayan, Nandini;
- Jakobsdottir, Johanna;
- Kunkle, Brian W;
- Boland, Anne;
- Raybould, Rachel;
- Bis, Joshua C;
- Martin, Eden R;
- Grenier-Boley, Benjamin;
- Heilmann-Heimbach, Stefanie;
- Chouraki, Vincent;
- Kuzma, Amanda B;
- Sleegers, Kristel;
- Vronskaya, Maria;
- Ruiz, Agustin;
- Graham, Robert R;
- Olaso, Robert;
- Hoffmann, Per;
- Grove, Megan L;
- Vardarajan, Badri N;
- Hiltunen, Mikko;
- Nöthen, Markus M;
- White, Charles C;
- Hamilton-Nelson, Kara L;
- Epelbaum, Jacques;
- Maier, Wolfgang;
- Choi, Seung-Hoan;
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- Herms, Stefan;
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- Funk, Cory C;
- Derbois, Céline;
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- Li, Hongdong;
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- Squassina, Alessio;
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- Medway, Christopher;
- Jian, Xueqiu;
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- Lin, Honghuang;
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- McGuinness, Bernadette;
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- Craig, David;
- Johnston, Janet;
- Gill, Michael;
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- Mesulam, Marsel;
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- Miller, Carol A;
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- Pankratz, Vernon S;
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- Reisberg, Barry;
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- Rosen, Howard J;
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- Schneider, Julie A;
- Schneider, Lon S;
- Seeley, William W;
- Smith, Amanda G;
- Sonnen, Joshua A;
- Spina, Salvatore;
- Stern, Robert A;
- Swerdlow, Russell H;
- Tanzi, Rudolph E;
- Thornton-Wells, Tricia A;
- Trojanowski, John Q;
- Troncoso, Juan C;
- Van Deerlin, Vivianna M;
- Van Eldik, Linda J;
- Vinters, Harry V;
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- Weintraub, Sandra;
- Welsh-Bohmer, Kathleen A;
- Wilhelmsen, Kirk C;
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- Wingo, Thomas S;
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- Yu, Chang-En;
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- Golamaully, Feroze;
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- Thonberg, Hakan;
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- Kilander, Lena;
- Brundin, RoseMarie;
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- Haapasalo, Annakaisa;
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- O'Donnell, Christopher J;
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- Galimberti, Daniela;
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- Scarpini, Elio;
- Tsuang, Debby W;
- Mancuso, Michelangelo;
- Bonuccelli, Ubaldo;
- Winslow, Ashley R;
- Daniele, Antonio;
- Wu, Chuang-Kuo;
- Peters, Oliver;
- Nacmias, Benedetta;
- Riemenschneider, Matthias;
- Heun, Reinhard;
- Brayne, Carol;
- Rubinsztein, David C;
- Bras, Jose;
- Guerreiro, Rita;
- Al-Chalabi, Ammar;
- Shaw, Christopher E;
- Collinge, John;
- Mann, David;
- Tsolaki, Magda;
- Clarimón, Jordi;
- Sussams, Rebecca;
- Lovestone, Simon;
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- Owen, Michael J;
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- Mead, Simon;
- Goate, Alison M;
- Uitterlinden, Andre G;
- Holmes, Clive;
- Cruchaga, Carlos;
- Ingelsson, Martin;
- Bennett, David A;
- Powell, John;
- Golde, Todd E;
- Graff, Caroline;
- De Jager, Philip L;
- Morgan, Kevin;
- Ertekin-Taner, Nilufer;
- Combarros, Onofre;
- Psaty, Bruce M;
- Passmore, Peter;
- Younkin, Steven G;
- Berr, Claudine;
- Gudnason, Vilmundur;
- Rujescu, Dan;
- Dickson, Dennis W;
- Dartigues, Jean-François;
- DeStefano, Anita L;
- Ortega-Cubero, Sara;
- Hakonarson, Hakon;
- Campion, Dominique;
- Boada, Merce;
- Kauwe, John Keoni;
- Farrer, Lindsay A;
- Van Broeckhoven, Christine;
- Ikram, M Arfan;
- Jones, Lesley;
- Haines, Jonathan L;
- Tzourio, Christophe;
- Launer, Lenore J;
- Escott-Price, Valentina;
- Mayeux, Richard;
- Deleuze, Jean-François;
- Amin, Najaf;
- Holmans, Peter A;
- Pericak-Vance, Margaret A;
- Amouyel, Philippe;
- van Duijn, Cornelia M;
- Ramirez, Alfredo;
- Wang, Li-San;
- Lambert, Jean-Charles;
- Seshadri, Sudha;
- Williams, Julie;
- Schellenberg, Gerard D
Published Web Location
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039/No data is associated with this publication.
Abstract
Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.
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