UC Davis

AbstractPost-acute sequelae of COVID-19 (PASC), or “long COVID”, is a debilitating chronic condition many COVID-19 survivors continuously suffer from for 12 weeks after their initial Sars-Cov-2 infection. The condition is considered a “second pandemic” that also affects millions. Symptomatic and severe COVID-19 has been recognized as a risk factor for long COVID. Risk for symptomatic COVID-19 is associated with vascular comorbidities such as hypertension, cardiovascular disease (CVD), and diabetes, and migraine shares these comorbidities. Migraine is a debilitating, neurologic condition that affects 12-15% of the general population. A retrospective cross-sectional study was conducted on de-identified patient data from the University of California COVID Research Data Set (UC CORDS) using informatics methods and tools. The primary aim was to assess whether COVID-positive migraineurs were significantly at risk for long COVID. The secondary aims were to identify confounders by stratum-specific risk ratio analysis and to find out if the presence of hypertension, CVD, or diabetes in COVID-positive migraineurs is also associated with long COVID. History of migraine in COVID-19 patients was found significantly associated with long COVID (RR 2.45, 95% CI: (2.64, 2.88), p-value = <0.0001). Stratum-specific risk ratio analysis found that long COVID was significantly associated with the presence of primary hypertension (RR 2.14, 95% CI: (1.60, 2.87), p-value <0.0001), CVD (RR 1.81, 95% CI: (1.19, 2.76), p-value = 0.008), or type 2 diabetes mellitus (RR 1.85, 95% CI: (1.23, 2.79), p-value = 0.005). in specifically female COVID-positive migraineurs younger than 65 years old. This thesis also aims to be a showcase for UC CORDS for future COVID-19 researchers.