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When Deletions Gain Functions: Commandeering Epigenetic Mechanisms
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https://doi.org/10.1016/j.ccr.2014.07.021Abstract
Recurrent chromosomal deletions in cancer are typically thought to harbor tumor suppressors. In a recent publication in Nature, Northcott and colleagues identify a novel region of structural variation in medulloblastoma that leads to oncogenic activation of GFI1B and GFI1 by repositioning these genes next to super-enhancers.
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