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Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

  • Author(s): Roose, Jeroen
  • Iwig, JS
  • Vercoulen, Y
  • Das, R
  • Barros, T
  • Limnander, A
  • Che, Y
  • Pelton, JG
  • Wemmer, DE
  • Roose, JP
  • Kuriyan, J
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3728621?pdf=render
No data is associated with this publication.
Abstract

RasGRP1 and SOS are Ras-specific nucleotide exchange factors that have distinct roles in lymphocyte development. RasGRP1 is important in some cancers and autoimmune diseases but, in contrast to SOS, its regulatory mechanisms are poorly understood. Activati

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