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Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model.

  • Author(s): Lwin, Thinzar M
  • Miyake, Kentaro
  • Murakami, Takashi
  • DeLong, Jonathan C
  • Amirfakhri, Siamak
  • Filemoni, Filemoni
  • Yoon, Sang Nam
  • Yazaki, Paul J
  • Shivley, John E
  • Datnow, Brian
  • Clary, Bryan M
  • Hoffman, Robert M
  • Bouvet, Michael
  • et al.
Abstract

Pancreatic cancer is a highly lethal disease in part due to incomplete tumor resection. Targeting by tumor-specific antibodies conjugated with a fluorescent label can result in selective labeling of cancer in vivo for surgical navigation. In the present study, we describe a patient-derived orthotopic xenograft model of pancreatic cancer that recapitulated the disease on a gross and microscopic level, along with physiologic clinical manifestations. We additionally show that the use of an anti-CEA antibody conjugated to the near-infrared (NIR) fluorescent dye, IRDye800CW, can selectively highlight the pancreatic cancer and its metastases in this model with a tumor-to-background ratio of 3.5 (SEM 0.9). The present results demonstrate the clinical potential of this labeling technique for fluorescence-guided surgery of pancreatic cancer.

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