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Structure of an HIV-2 gp120 in Complex with CD4.

  • Author(s): Davenport, Yunji W
  • West, Anthony P
  • Bjorkman, Pamela J
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733984/
No data is associated with this publication.
Abstract

HIV-2 is a nonpandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term nonprogression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30 to 40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0-Å structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence.

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