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Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor

Published Web Location

https://doi.org/10.1038/nature17978
Abstract

The cancer drug rocaglamide A cements the RNA helicase eIF4A on polypurine sequences and thereby prevents scanning of the 43S subunit along the messenger RNA, highlighting how a drug can act by stabilizing sequence-selective RNA–protein interactions.

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