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Open Access Publications from the University of California

Non-invasive optical mapping of the piglet brain in real time

  • Author(s): Fantini, S
  • Franceschini, MA
  • Gratton, E
  • Hueber, D
  • Rosenfeld, W
  • Maulik, D
  • Stubblefield, PG
  • Stankovic, MR
  • et al.

We have performed non-invasive, real-time optical mapping of the piglet brain during a subcortical injection of autologous blood. The time resolution of the optical maps is 192 ms, thus allowing us to generate a real-time video of the growing subcortical hematoma. The increased absorption at the site of blood injection is accompanied by a decreased absorption at the contralateral brain side. This contralateral decrease in the optical absorption and the corresponding time traces of the cerebral hemoglobin parameters are consistent with a reduced cerebral blood flow caused by the increased intracranial pressure. © 1999 Optical Society of America.

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