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Open Access Publications from the University of California

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

  • Author(s): Mucke, Lennart
  • Kreitzer, Anatol
  • Suberbielle, E
  • Sanchez, PE
  • Kravitz, AV
  • Wang, X
  • Ho, K
  • Eilertson, K
  • Devidze, N
  • Kreitzer, AC
  • et al.

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We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in lea

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