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Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

Published Web Location

http://europepmc.org/articles/PMC3637871?pdf=render
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Abstract

We show that a natural behavior, exploration of a novel environment, causes DNA double-strand breaks (DSBs) in neurons of young adult wild-type mice. DSBs occurred in multiple brain regions, were most abundant in the dentate gyrus, which is involved in lea

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