Imaging nanoparticle flow using magneto-motive optical Doppler tomography
- Author(s): Kim, J
- Oh, J
- Milner, TE
- Nelson, JS
- et al.
Published Web Locationhttps://doi.org/10.1088/0957-4484/18/3/035504
We introduce a novel approach for imaging solutions of superparamagnetic iron oxide (SPIO) nanoparticles using magneto-motive optical Doppler tomography (MM-ODT). MM-ODT combines an externally applied temporally oscillating high-strength magnetic field with ODT to detect nanoparticles flowing through a microfluidic channel. A solenoid with a cone-shaped ferrite core extensively increased the magnetic field strength (Bmax ≤ 1T, ) at the tip of the core and also focused the magnetic field in microfluidic channels containing nanoparticle solutions. Nanoparticle contrast was demonstrated in a microfluidic channel filled with an SPIO solution by imaging the Doppler frequency shift which was observed independently of the nanoparticle flow rate and direction. Results suggest that MM-ODT may be applied to image Doppler shift of SPIO nanoparticles in microfluidic flows with high contrast. © IOP Publishing Ltd.
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