In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy
- Author(s): Saager, RB
- Sharif, A
- Kelly, KM
- Durkin, AJ
- et al.
Published Web Locationhttps://doi.org/10.1117/1.JBO.21.5.057001
© 2016 The Authors. Skin is a highly structured tissue, raising concerns as to whether skin pigmentation due to epidermal melanin may confound accurate measurements of underlying hemodynamics. Using both venous and arterial cuff occlusions as a means of inducing differential hemodynamic perturbations, we present analyses of spectra limited to the visible or near-infrared regime, in addition to a layered model approach. The influence of melanin, spanning Fitzpatrick skin types I to V, on underlying estimations of hemodynamics in skin as interpreted by these spectral regions are assessed. The layered model provides minimal cross-talk between melanin and hemodynamics and enables removal of problematic correlations between measured tissue oxygenation estimates and skin phototype.
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