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Endogenous antigen tunes the responsiveness of naive B cells but not T cells
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https://doi.org/10.1038/nature11311Abstract
Mature B cells encounter antigens during development that induce anergy or functional unresponsiveness; this large reservoir of dormant autoreactive B cells may serve as a pool of extended antibody specificity for purposes of protective immunity, as well as the source of pathogenic autoantibodies that characterize rheumatic diseases such as systemic lupus erythematosus.
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