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Protic‐Solvent‐Mediated Cycloisomerization of Quinoline and Isoquinoline Propargylic Alcohols: Syntheses of (±)‐3‐Demethoxyerythratidinone and (±)‐Cocculidine


Putting the "benz" in indolizinones: A cycloisomerization approach to benz[g]indolizinones and benz[e]indolizinones provides the first general route to these unique azacycles (see example). The utility of the benzindolizinone products was demonstrated by the application of this method to the total synthesis of the Erythrina alkaloids 3-demethoxyerythratidinone and cocculidine.

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