Skip to main content
eScholarship
Open Access Publications from the University of California

UC San Diego

UC San Diego Previously Published Works bannerUC San Diego

Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings.

  • Author(s): Denning, David W
  • Page, Iain D
  • Chakaya, Jeremiah
  • Jabeen, Kauser
  • Jude, Cecilia M
  • Cornet, Muriel
  • Alastruey-Izquierdo, Ana
  • Bongomin, Felix
  • Bowyer, Paul
  • Chakrabarti, Arunaloke
  • Gago, Sara
  • Guto, John
  • Hochhegger, Bruno
  • Hoenigl, Martin
  • Irfan, Muhammad
  • Irurhe, Nicholas
  • Izumikawa, Koichi
  • Kirenga, Bruce
  • Manduku, Veronica
  • Moazam, Samihah
  • Oladele, Rita O
  • Richardson, Malcolm D
  • Tudela, Juan Luis Rodriguez
  • Rozaliyani, Anna
  • Salzer, Helmut JF
  • Sawyer, Richard
  • Simukulwa, Nasilele F
  • Skrahina, Alena
  • Sriruttan, Charlotte
  • Setianingrum, Findra
  • Wilopo, Bayu AP
  • Cole, Donald C
  • Getahun, Haileyesus
  • et al.
Abstract

Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View