Skip to main content
eScholarship
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Elaboration of a multispecies model of solid tumor growth with tumor-host interactions

  • Author(s): Konstorum, A;
  • Sprowl, SA;
  • Lander, AD;
  • Waterman, ML;
  • Lowengrub, JS
  • et al.
Abstract

There has been increasing evidence of the critical effects of microenvironmental influence on tumor growth and metastasis. In this report, we extend a multispecies continuum model of solid tumor growth to include interaction of the tumor with its microenvironment. This new model, which incorporates reported interactions between tumor-and stroma-derived chemical signals, predicts a nonlinear response to host factors: increased growth and asymmetry of the tumor at low levels of stromal fibroblast-produced Hepatocyte Growth Factor / Scatter Factor (HGF/SF), and reduced growth at high levels.We test the model predictions using colon cancer initiating cell (CCIC) spheroids grown in media in varying concentrations of HGF. The experiments show qualitatively similar behavior to the model predictions. We plan to use the experimental studies to calibrate the mathematical model, and to use the mathematical model to make predictions regarding tumor behavior in order to guide future experimental studies.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View