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Open Access Publications from the University of California

Correlation of (1→3)-β-D-glucan with other inflammation markers in chronically HIV infected persons on suppressive antiretroviral therapy.

  • Author(s): Hoenigl, Martin;
  • de Oliveira, Michelli Faria;
  • Pérez-Santiago, Josué;
  • Zhang, Yonglong;
  • Woods, Steven Paul;
  • Finkelman, Malcolm;
  • Gianella, Sara
  • et al.

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We evaluated associations between levels of BDG and other biomarkers of inflammation in blood from 41 virologically suppressed persons with chronic HIV-infection. We found a significant correlation between BDG and neopterin levels (r=0.68), and trends to significance for correlations with other inflammation markers (tumor-necrosis-factor-α: r=0.30; interleukin-8: r=0.30; interleukin-6: r=0.28). In conclusion, BDG levels correlated with inflammation markers in a cohort of virologically suppressed individuals with chronic HIV infection. Future studies are needed to evaluate whether BDG may be a marker for morbidity in chronic HIV infection.

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