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Cancer outcomes among Parkinson's disease patients with leucine rich repeat kinase 2 mutations, idiopathic Parkinson's disease patients, and nonaffected controls
- Agalliu, Ilir;
- Ortega, Roberto A;
- San Luciano, Marta;
- Mirelman, Anat;
- Pont‐Sunyer, Claustre;
- Brockmann, Kathrin;
- Vilas, Dolores;
- Tolosa, Eduardo;
- Berg, Daniela;
- Warø, Bjørg;
- Glickman, Amanda;
- Raymond, Deborah;
- Inzelberg, Rivka;
- Ruiz‐Martinez, Javier;
- Mondragon, Elisabet;
- Friedman, Eitan;
- Hassin‐Baer, Sharon;
- Alcalay, Roy N;
- Mejia‐Santana, Helen;
- Aasly, Jan;
- Foroud, Tatiana;
- Marder, Karen;
- Giladi, Nir;
- Bressman, Susan;
- Saunders‐Pullman, Rachel
- et al.
Published Web Location
https://doi.org/10.1002/mds.27807Abstract
Background
Increased cancer risk has been reported in Parkinson's disease (PD) patients carrying the leucine rich repeat kinase 2 (LRRK2) G2019S mutation (LRRK2-PD) in comparison with idiopathic PD (IPD). It is unclear whether the elevated risk would be maintained when compared with unaffected controls.Methods
Cancer outcomes were compared among 257 LRRK2-PD patients, 712 IPD patients, and 218 controls recruited from 7 LRRK2 consortium centers using mixed-effects logistic regression. Data were then pooled with a previous study to examine cancer risk between 401 LRRK2-PD and 1946 IPD patients.Results
Although cancer prevalence was similar among LRRK2-PD patients (32.3%), IPD patients (27.5%), and controls (27.5%; P = 0.33), LRRK2-PD had increased risks of leukemia (odds ratio [OR] = 4.55; 95% confidence interval [CI], 1.46-10.61) and skin cancer (OR = 1.61; 95% CI, 1.09-2.37). In the pooled analysis, LRRK2-PD patients had also elevated risks of leukemia (OR = 9.84; 95% CI, 2.15-44.94) and colon cancer (OR = 2.34; 95% CI, 1.15-4.74) when compared with IPD patients.Conclusions
The increased risks of leukemia as well as skin and colon cancers among LRRK2-PD patients suggest that LRRK2 mutations heighten risks of certain cancers. © 2019 International Parkinson and Movement Disorder Society.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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