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Open Access Publications from the University of California

Acceleration of cerebral ventricular expansion in the Cardiovascular Health Study.

  • Author(s): Carmichael, Owen T
  • Kuller, L H
  • Lopez, O L
  • Thompson, P M
  • Dutton, R A
  • Lu, A
  • Lee, S E
  • Lee, J Y
  • Aizenstein, H J
  • Meltzer, C C
  • Liu, Y
  • Toga, A W
  • Becker, J T
  • et al.

Interactions between prevalent late-life medical conditions and expansion of the cerebral ventricles are not well understood. Thirty elderly subjects received three magnetic resonance (MR) scans each, in 1997-1999, 2002-2004, and 2003-2005. A linear expansion model of MR-measured lateral ventricle volume was estimated for each subject by fitting a line to a plot of their 1997-1999 and 2002-2004 volumes as a function of time. Acceleration in ventricular expansion was defined as the deviation between the 2003-2005 volumes measured from MR and the 2003-2005 volumes predicted by the linear expansion model. Ventricular acceleration was analyzed in a multivariate model with age, race, history of heart disease, diabetes, and hypertension as fixed effects. Ventricular acceleration was significantly higher in non-whites, diabetics, and those without heart disease (p<0.05). Ventricular acceleration was higher in subjects with a history of hypertension, but the difference was not statistically significant (p=0.08). Acceleration of ventricular expansion in the elderly may be related to demographic and cardiovascular factors.

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