Hydrogels for brain repair after stroke: an emerging treatment option.
- Author(s): Nih, Lina Ratiba
- Carmichael, Stanley Thomas
- Segura, Tatiana
- et al.
Published Web Locationhttps://doi.org/10.1016/j.copbio.2016.04.021
Stroke disability is the only major disease without an effective treatment. The substantial clinical burden of stroke in disabled survivors and the lack of a medical therapy that promotes recovery provide an opportunity to explore the use of biomaterials to promote brain repair after stroke. Hydrogels can be injected as a liquid and solidify in situ to form a gelatinous solid with similar mechanical properties to the brain. These biomaterials have been recently explored to generate pro-repair environments within the damaged organ. This review highlights the clinical problem of stroke treatment and discusses recent advances in using in situ forming hydrogels for brain repair.