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Open Access Publications from the University of California

New highlights on stroma-epithelial interactions in breast cancer.

  • Author(s): Barcellos-Hoff, Mary Helen
  • Medina, Daniel
  • et al.

Published Web Location

https://doi.org/10.1186/bcr972
Abstract

Although the stroma in which carcinomas arise has been previously regarded as a bystander to the clonal expansion and acquisition of malignant characteristics of tumor cells, it is now generally acknowledged that stromal changes are required for the establishment of cancer. In the present article, we discuss three recent publications that highlight the complex role the stroma has during the development of cancer and the potential for targeting the stroma by therapeutic approaches.

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