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Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.

  • Author(s): Haiman, Christopher
  • Chen, Gary
  • Blot, William
  • Strom, Sara
  • Berndt, Sonja
  • Kittles, Rick
  • Rybicki, Benjamin
  • Isaacs, William
  • Ingles, Sue
  • Stanford, Janet
  • Diver, W
  • Witte, John
  • Hsing, Ann
  • Nemesure, Barbara
  • Rebbeck, Timothy
  • Cooney, Kathleen
  • Xu, Jianfeng
  • Kibel, Adam
  • Hu, Jennifer
  • John, Esther
  • Gueye, Serigne
  • Watya, Stephen
  • Signorello, Lisa
  • Hayes, Richard
  • Wang, Zhaoming
  • Yeboah, Edward
  • Tettey, Yao
  • Cai, Qiuyin
  • Kolb, Suzanne
  • Ostrander, Elaine
  • Zeigler-Johnson, Charnita
  • Yamamura, Yuko
  • Neslund-Dudas, Christine
  • Haslag-Minoff, Jennifer
  • Wu, William
  • Thomas, Venetta
  • Allen, Glenn
  • Murphy, Adam
  • Chang, Bao-Li
  • Zheng, S
  • Leske, M
  • Wu, Suh-Yuh
  • Ray, Anna
  • Hennis, Anselm
  • Thun, Michael
  • Carpten, John
  • Casey, Graham
  • Carter, Erin
  • Duarte, Edder
  • Xia, Lucy
  • Sheng, Xin
  • Wan, Peggy
  • Pooler, Loreall
  • Cheng, Iona
  • Monroe, Kristine
  • Schumacher, Fredrick
  • Le Marchand, Loic
  • Kolonel, Laurence
  • Chanock, Stephen
  • Van Den Berg, David
  • Stram, Daniel
  • Henderson, Brian
  • et al.

Published Web Location

https://doi.org/10.1038/ng.839
Abstract

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

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