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Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.

  • Author(s): Haiman, Christopher A
  • Chen, Gary K
  • Blot, William J
  • Strom, Sara S
  • Berndt, Sonja I
  • Kittles, Rick A
  • Rybicki, Benjamin A
  • Isaacs, William B
  • Ingles, Sue A
  • Stanford, Janet L
  • Diver, W Ryan
  • Witte, John S
  • Hsing, Ann W
  • Nemesure, Barbara
  • Rebbeck, Timothy R
  • Cooney, Kathleen A
  • Xu, Jianfeng
  • Kibel, Adam S
  • Hu, Jennifer J
  • John, Esther M
  • Gueye, Serigne M
  • Watya, Stephen
  • Signorello, Lisa B
  • Hayes, Richard B
  • Wang, Zhaoming
  • Yeboah, Edward
  • Tettey, Yao
  • Cai, Qiuyin
  • Kolb, Suzanne
  • Ostrander, Elaine A
  • Zeigler-Johnson, Charnita
  • Yamamura, Yuko
  • Neslund-Dudas, Christine
  • Haslag-Minoff, Jennifer
  • Wu, William
  • Thomas, Venetta
  • Allen, Glenn O
  • Murphy, Adam
  • Chang, Bao-Li
  • Zheng, S Lilly
  • Leske, M Cristina
  • Wu, Suh-Yuh
  • Ray, Anna M
  • Hennis, Anselm JM
  • Thun, Michael J
  • Carpten, John
  • Casey, Graham
  • Carter, Erin N
  • Duarte, Edder R
  • Xia, Lucy Y
  • Sheng, Xin
  • Wan, Peggy
  • Pooler, Loreall C
  • Cheng, Iona
  • Monroe, Kristine R
  • Schumacher, Fredrick
  • Le Marchand, Loic
  • Kolonel, Laurence N
  • Chanock, Stephen J
  • Van Den Berg, David
  • Stram, Daniel O
  • Henderson, Brian E
  • et al.

Published Web Location

https://doi.org/10.1038/ng.839
Abstract

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 × 10(-13)). The frequency of the risk allele is ∼5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

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