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Immune regulation of bone loss by Th17 cells.

  • Author(s): Adamopoulos, Iannis E
  • Bowman, Edward P
  • et al.

Published Web Location

https://doi.org/10.1186/ar2502
Abstract

A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.

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