Immune regulation of bone loss by Th17 cells.
- Author(s): Adamopoulos, Iannis E
- Bowman, Edward P
- et al.
Published Web Locationhttps://doi.org/10.1186/ar2502
A significant macrophage and T-cell infiltrate commonly occurs in inflammatory joint conditions such as rheumatoid arthritis that have significant bone destruction. Cytokines produced by activated macrophages and T cells are implicated in arthritis pathogenesis and are involved in osteoclast-mediated bone resorption. The scope of the present review is to analyze current knowledge and to provide a better understanding of how macrophage-derived factors promote the differentiation of a novel T-helper subset (Th17) that promotes osteoclast formation and activation.