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REC protein family expansion by the emergence of a new signaling pathway.
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https://doi.org/10.1128/mbio.02622-23Abstract
We explore when and why large classes of proteins expand into new sequence space. We used an unsupervised machine learning approach to observe the sequence landscape of REC domains of bacterial response regulator proteins. We find that within-gene recombination can switch effector domains and, consequently, change the regulatory context of the duplicated protein.
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