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Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
- Yang, Xia;
- Deignan, Joshua L;
- Qi, Hongxiu;
- Zhu, Jun;
- Qian, Su;
- Zhong, Judy;
- Torosyan, Gevork;
- Majid, Sana;
- Falkard, Brie;
- Kleinhanz, Robert R;
- Karlsson, Jenny;
- Castellani, Lawrence W;
- Mumick, Sheena;
- Wang, Kai;
- Xie, Tao;
- Coon, Michael;
- Zhang, Chunsheng;
- Estrada-Smith, Daria;
- Farber, Charles R;
- Wang, Susanna S;
- van Nas, Atila;
- Ghazalpour, Anatole;
- Zhang, Bin;
- MacNeil, Douglas J;
- Lamb, John R;
- Dipple, Katrina M;
- Reitman, Marc L;
- Mehrabian, Margarete;
- Lum, Pek Y;
- Schadt, Eric E;
- Lusis, Aldons J;
- Drake, Thomas A
Published Web Location
https://doi.org/10.1038/ng.325Abstract
Thomas Drake and colleagues report the results of knockout or transgene introduction for nine obesity candidate genes in mice. Eight of the nine mutations result in significant changes in obesity-related traits, validating their previously developed approach for identifying candidate genes involved in particular phenotypes. They further identify related metabolic pathways that are altered by manipulation of the eight genes.
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