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FMRP(1-297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome.

  • Author(s): Zhan, Xiaoqin
  • Asmara, Hadhimulya
  • Cheng, Ning
  • Sahu, Giriraj
  • Sanchez, Eduardo
  • Zhang, Fang-Xiong
  • Zamponi, Gerald W
  • Rho, Jong M
  • Turner, Ray W
  • et al.
Abstract

Fragile X Syndrome results from a loss of Fragile X Mental Retardation Protein (FMRP). We now show that FMRP is a member of a Cav3-Kv4 ion channel complex that is known to regulate A-type potassium current in cerebellar granule cells to produce mossy fiber LTP. Mossy fiber LTP is absent in Fmr1 knockout (KO) mice but is restored by FMRP(1-297)-tat peptide. This peptide further rapidly permeates the blood-brain barrier to enter cells across the cerebellar-cortical axis that restores the balance of protein translation for at least 24 h and transiently reduces elevated levels of activity of adult Fmr1 KO mice in the Open Field Test. These data reveal that FMRP(1-297)-tat can improve function from the levels of protein translation to synaptic efficacy and behaviour in a model of Fragile X syndrome, identifying a potential therapeutic strategy for this genetic disorder.

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