Collimated superfine x-ray beam based x-ray luminescence computed tomography.
- Author(s): Zhang, Wei
- Zhu, Dianwen
- Lun, Michael
- Li, Changqing
- et al.
Published Web Locationhttps://doi.org/10.3233/xst-17265
X-ray luminescence computed tomography (XLCT) is a hybrid imaging modality with the potential to achieve a spatial resolution up to several hundred micrometers for targets embedded in turbid media with a depth larger than several millimeters. In this paper, we report a high spatial resolution XLCT imaging system with a collimated superfine x-ray beam in imaging the deeply embedded targets. A collimator with a 100 micrometer pinhole was mounted in the front of a powerful x-ray tube to generate a superfine x-ray pencil beam with a beam diameter of 0.175 mm. For the phantom experiment of four capillary targets with an edge-to-edge distance of 400 micrometers, we were able to reconstruct the targets in a depth of 5 mm successfully, which were validated with microCT images. We have further investigated the effect of different x-ray beam diameters on the reconstructed XLCT images with numerical simulations. Our results indicate that XLCT has the ability to image successfully multiple deeply embedded targets when the collimated x-ray beam diameter is less than or equal to the target edge-to-edge distance. Our numerical simulations also demonstrate that XLCT can achieve a spatial resolution of 200 micrometers for targets embedded at a depth of 5 mm if the scanning beam has a diameter of 100 micrometers.