DNA variation at the Sod locus of Drosophila melanogaster: an unfolding story of natural selection.
- Author(s): Hudson, RR
- Sáez, AG
- Ayala, FJ
- et al.
Published Web Locationhttps://doi.org/10.1073/pnas.94.15.7725
Patterns of variation at the Sod locus of Drosophila melanogaster suggest that the protein polymorphism at this locus has very recently arisen. In addition, it appears that a previously rare DNA variant has been recently and rapidly driven to intermediate frequency. From the size of the region (>20 kb) that has been swept along with this rare variant, and patterns of linkage disequilibrium in the region, it is inferred that strength of selection was large (s > 0.01) and that the sweep occurred more than 25,000 generations ago. In addition, there are striking similarities to patterns of variation observed at the Est6 and Est-P loci, which are located approximately 1,000 kb from Sod.