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How good can cryo-EM become?

Published Web Location

https://www.nature.com/nmeth/journal/v13/n1/full/nmeth.3695.html
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Abstract

The suddenness with which single-particle cryo-electron microscopy (cryo-EM) has emerged as a method for determining high-resolution structures of biological macromolecules invites the questions, how much better can this technology get, and how fast is that likely to happen? Though we can rightly celebrate the maturation of cryo-EM as a high-resolution structure-determination tool, I believe there still are many developments to look forward to.

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