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Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter

  • Author(s): Stroud, Robert
  • Zamvil, Scott
  • Cree, Bruce
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3405197?pdf=render
No data is associated with this publication.
Abstract

Objective: Aquaporin 4 (AQP4)-specific autoantibodies in neuromyelitis optica (NMO) are immunoglobulin (Ig)G1, a T cell-dependent Ig subclass, indicating that AQP4-specific T cells participate in NMO pathogenesis. Our goal was to identify and characterize

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