Aquaporin 4-specific T cells in neuromyelitis optica exhibit a Th17 bias and recognize Clostridium ABC transporter
- Author(s): Stroud, Robert
- Zamvil, Scott
- Cree, Bruce
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3405197?pdf=render
Objective: Aquaporin 4 (AQP4)-specific autoantibodies in neuromyelitis optica (NMO) are immunoglobulin (Ig)G1, a T cell-dependent Ig subclass, indicating that AQP4-specific T cells participate in NMO pathogenesis. Our goal was to identify and characterize