Transcriptional Regulation of Apolipoprotein A5 Gene Expression by theNuclear Receptor ROR alpha
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Transcriptional Regulation of Apolipoprotein A5 Gene Expression by theNuclear Receptor ROR alpha

  • Author(s): Genoux, Annelise
  • Dehondt, Helene
  • Helleboid-Chapman, Audrey
  • Duhem, Christian
  • Hum, Dean W.
  • Martin, Genevieve
  • Pennacchio, Len
  • Staels, Bart
  • Fruchart-Najib, Jamila
  • Fruchart, Jean-Charles
  • et al.
Abstract

Apolipoprotein A5 has recently been identified as a crucial determinant of plasma triglyceride levels. Our results showed that RORa up-regulates human APOA5 but has no effect on mouse apoa5 promoter. These data suggest an additional important physiological role for RORa in the regulation of genes involved in plasma triglyceride homeostasis in human and probably in the development of atherosclerosis

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