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Open Access Publications from the University of California

Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis.

  • Author(s): Graf, Jonathan
  • Imboden, John
  • Coffey, G
  • Betz, A
  • Stephens, G
  • Hua, P
  • Sinha, U
  • et al.

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BACKGROUND: Selective disruption of the spleen tyrosine kinase (Syk) represents a novel strategy to control B-cell functional responses by inhibition of B-cell antigen receptor (BCR) signaling. PRT062607 (P505-15) is a highly selective small molecule Syk i

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