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Acute thrombotic thrombocytopenic purpura following orthopedic surgery

Published Web Location

https://doi.org/10.1002/jca.10027
Abstract

Release of unusually large von Willibrand factor (UL v WF)vmultimers and a deficiency of vWF metalloprotease may result in thrombotic thromocytopenic purpura (TTP), a life threatening disease. Surgery has been associated with TTP, probably by releasing massive amounts of UL v WF. An association bwteeen TTP and orthopedic surgery has never been reported inthe literature. We report a case of TTP following a total knee replacement surgery in which prior use of ticlopidine mighthave played a role.

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