Colloidal aggregation causes inhibition of G protein-coupled receptors
- Author(s): Shoichet, Brian
- Sassano, MF
- Doak, AK
- Roth, BL
- Shoichet, BK
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3613083?pdf=render
Colloidal aggregation is the dominant mechanism for artifactual inhibition of soluble proteins, and controls against it are now widely deployed. Conversely, investigating this mechanism for membrane-bound receptors has proven difficult. Here we investigate
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