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Colloidal aggregation causes inhibition of G protein-coupled receptors

  • Author(s): Shoichet, Brian
  • Sassano, MF
  • Doak, AK
  • Roth, BL
  • Shoichet, BK
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3613083?pdf=render
No data is associated with this publication.
Abstract

Colloidal aggregation is the dominant mechanism for artifactual inhibition of soluble proteins, and controls against it are now widely deployed. Conversely, investigating this mechanism for membrane-bound receptors has proven difficult. Here we investigate

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