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Open Access Publications from the University of California

Asymmetric gold-catalyzed lactonizations in water at room temperature.

  • Author(s): Handa, Sachin
  • Lippincott, Daniel J
  • Aue, Donald H
  • Lipshutz, Bruce H
  • et al.

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Asymmetric gold-catalyzed hydrocarboxylations are reported that show broad substrate scope. The hydrophobic effect associated with in situ-formed aqueous nanomicelles gives good to excellent ee's of product lactones. In-flask product isolation, along with the recycling of the catalyst and the reaction medium, are combined to arrive at an especially environmentally friendly process.

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