Skip to main content
Download PDF
- Main
An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
- Chung, Alicia S;
- Wu, Xiumin;
- Zhuang, Guanglei;
- Ngu, Hai;
- Kasman, Ian;
- Zhang, Jianhuan;
- Vernes, Jean-Michel;
- Jiang, Zhaoshi;
- Meng, Y Gloria;
- Peale, Franklin V;
- Ouyang, Wenjun;
- Ferrara, Napoleone
Published Web Location
https://doi.org/10.1038/nm.3291Abstract
The efficacy of anti-angiogenic therapy for cancer could be improved if tumor resistance mechanisms were better understood. In this report, Napoleone Ferrara and his colleagues uncover a tumor resistance mechanism to VEGF-neutralizing antibodies triggered by IL-17, the hallmark cytokine of TH17 cells.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.