Lack of association of the apoE4 allele with hippocampal sclerosis dementia
- Author(s): Troncoso, JC
- Kawas, CH
- Chang, CK
- Folstein, MF
- Hedreen, JC
- et al.
Published Web Locationhttps://doi.org/10.1016/0304-3940(96)12331-4
We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the ~40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.