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Lack of association of the apoE4 allele with hippocampal sclerosis dementia

  • Author(s): Troncoso, JC
  • Kawas, CH
  • Chang, CK
  • Folstein, MF
  • Hedreen, JC
  • et al.
Abstract

We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the ~40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.

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