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Variation in Trans-3′-Hydroxycotinine Glucuronidation Does Not Alter the Nicotine Metabolite Ratio or Nicotine Intake

  • Author(s): Benowitz, Neal
  • Zhu, AZX
  • Zhou, Q
  • Cox, LS
  • Ahluwalia, JS
  • Benowitz, NL
  • Tyndale, RF
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3732272?pdf=render
No data is associated with this publication.
Abstract

Background: CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3′-hydroxycotinine (3HC). The ratio of 3HC to cotinine (the "nicotine metabolite ratio", NMR) is an in vivo marker for the rate

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