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A Twist between ROS and Sperm-Mediated Intergenerational Epigenetic Inheritance
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https://doi.org/10.1016/j.molcel.2020.04.003Abstract
Yoshida et al. (2020) report in this issue of Molecular Cell that a paternal low-protein diet elevates ROS in the testicular germ cells, altering ATF7 activity and H3K9me2 abundance on target genes, including tRNA loci. These changes are maintained in spermatozoa, regulating tsRNA biogenesis, and together transmit intergenerational effects.
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