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Delineating CSF-1-dependent regulation of myeloid cell diversity in tumors
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https://doi.org/10.1080/2162402x.2015.1008871Abstract
Myeloid cells contribute to increased malignancy and poor prognosis in breast cancer. We demonstrate that anti-CSF-1R therapy depletes a cell population sharing characteristics of tumor-associated macrophages (TAMs) and dendritic cells (DCs). Intravital imaging combined with cellular characterization has refined our understanding of anti-CSF-1R therapy on the tumor microenvironment.
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