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Open Access Publications from the University of California

Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration.

  • Author(s): Moore, Anthony
  • Ansari, M
  • McKeigue, PM
  • Skerka, C
  • Hayward, C
  • Rudan, I
  • Vitart, V
  • Polasek, O
  • Armbrecht, A-M
  • Yates, JRW
  • Vatavuk, Z
  • et al.

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It is a longstanding puzzle why non-coding variants in the complement factor H (CFH) gene are more strongly associated with age-related macular degeneration (AMD) than functional coding variants that directly influence the alternative complement pathway. T

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