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Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain
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https://doi.org/10.1038/s41598-018-19913-xAbstract
The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.
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