Skip to main content
Open Access Publications from the University of California

UC Davis

UC Davis Previously Published Works bannerUC Davis

Transgenerational effects of binge drinking in a primate model: implications for human health



To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development.


Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating.


National primate research center.


Adult female rhesus monkeys.


Binge levels of ethanol, given twice weekly for 6 months before a standard in vitro fertilization cycle with or without embryo culture. With in vivo development, ethanol treatment continued until pregnancy was identified.

Main outcome measure(s)

Oocyte and cumulus/granulosa cell gene expression, embryo development to blastocyst, and pregnancy rate.


Embryo development in vitro was reduced; changes were found in oocyte and cumulus cell gene expression; and spontaneous abortion during very early gestation increased.


This study provides evidence that binge drinking can affect the developmental potential of oocytes even after alcohol consumption has ceased.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View