Direct and Propagated Effects of Small Molecules on Protein-Protein Interaction Networks.
- Author(s): Gestwicki, Jason
- Cesa, LC
- Mapp, AK
- Gestwicki, JE
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4547496?pdf=render
Networks of protein-protein interactions (PPIs) link all aspects of cellular biology. Dysfunction in the assembly or dynamics of PPI networks is a hallmark of human disease, and as such, there is growing interest in the discovery of small molecules that ei