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Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes

  • Author(s): Weiss, Lauren
  • Josowitz, R
  • Mulero-Navarro, S
  • Rodriguez, NA
  • Falce, C
  • Cohen, N
  • Ullian, EM
  • Rauen, KA
  • Sobie, EA
  • Gelb, BD
  • et al.

Published Web Location

http://europepmc.org/articles/PMC5032183?pdf=render
No data is associated with this publication.
Abstract

© 2016 The AuthorsGermline mutations in BRAF cause cardio-facio-cutaneous syndrome (CFCS), whereby 40% of patients develop hypertrophic cardiomyopathy (HCM). As the role of the RAS/MAPK pathway in HCM pathogenesis is unclear, we generated a human induced p

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