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Open Access Publications from the University of California

Creation of a Molluscan Cell Line


Through the National Sea Grant’s Oyster Disease Research Program, scientists from around the country are being funded to find approaches to restoring the ecological and commercial viability of oyster beds.This one-page publication highlights the efforts of Dr. Jane Burns of the Theodore Gildred Cancer Center at UC San Diego’s School of Medicine to create a genetically engineered,disease-resistant version of the commercially important oyster, Crassostrea virginica. Conceptually, this could be achieved by inserting appropriate genes from a horseshoe crab—the crab produces antimicrobial proteins that make it immune to disease—into an oyster genome. Though simple in theory, in practice it requires the development of many intermediary techniques and tools.

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