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Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by (129)Xe hyperCEST NMR.

  • Author(s): Finbloom, Joel A;
  • Slack, Clancy C;
  • Bruns, Carson J;
  • Jeong, Keunhong;
  • Wemmer, David E;
  • Pines, Alexander;
  • Francis, Matthew B
  • et al.
Abstract

We report a method for blocking interactions between (129)Xe and cucurbit[6]uril (CB6) until activation by a specific chemical event. We synthesized a CB6-rotaxane that allowed no (129)Xe interaction with the CB6 macrocycle component until a cleavage event released the CB6, which then produced a (129)Xe@CB6 NMR signal. This contrast-upon-activation (129)Xe NMR platform allows for modular synthesis and can be expanded to applications in detection and disease imaging.

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