High Throughput Sequencing Reveals Alterations in the Recombination Signatures with Diminishing Spo11 Activity
- Author(s): Fung, Jennifer
- Rockmill, B
- Lefrançois, P
- Voelkel-Meiman, K
- Oke, A
- Roeder, GS
- Fung, JC
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3814317?pdf=render
Spo11 is the topoisomerase-like enzyme responsible for the induction of the meiosis-specific double strand breaks (DSBs), which initiates the recombination events responsible for proper chromosome segregation. Nineteen PCR-induced alleles of SPO11 were ide
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