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High Throughput Sequencing Reveals Alterations in the Recombination Signatures with Diminishing Spo11 Activity

  • Author(s): Fung, Jennifer
  • Rockmill, B
  • Lefrançois, P
  • Voelkel-Meiman, K
  • Oke, A
  • Roeder, GS
  • Fung, JC
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3814317?pdf=render
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Abstract

Spo11 is the topoisomerase-like enzyme responsible for the induction of the meiosis-specific double strand breaks (DSBs), which initiates the recombination events responsible for proper chromosome segregation. Nineteen PCR-induced alleles of SPO11 were ide

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