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Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations.

  • Author(s): Aslan, Ivy R;
  • Campos, Guilherme M;
  • Calton, Melissa A;
  • Evans, Daniel S;
  • Merriman, Raphael B;
  • Vaisse, Christian
  • et al.
Abstract

Background

Heterozygous mutations in melanocortin-4 receptor (MC4R) are the most frequent genetic cause of obesity. Bariatric surgery is a successful treatment for severe obesity. The mechanisms of weight loss after bariatric surgery are not well understood.

Methods

Ninety-two patients who had Roux-en-Y gastric bypass (RYGB) surgery were screened for MC4R mutations. We compared percent excess weight loss (%EWL) in the four MC4R mutation carriers with that of two control groups: 8 matched controls and with the remaining 80 patients who underwent RYGB.

Results

Four patients were heterozygous for functionally significant MC4R mutations. In patients with MC4R mutations, the %EWL after RYGB (66% EWL) was not significantly different compared to matched controls (70% EWL) and non-matched controls (60% EWL) after 1 year of follow-up.

Conclusions

This study suggests that patients with heterozygous MC4R mutations also benefit from RYGB and that weight loss may be independent of the presence of such mutations.

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